VTN and ischemic stroke: Besides thrombosis, GPVI also plays a central role in thrombo-inflammatory pathologies as shown in models of acute lung injury and cerebral I/R injury in ischaemic stroke where platelets mainly drive detrimental inflammation, rather than thrombus formation.5,10,30,45,46 In these settings, GPVI may be activated by collagen/fibrin but also other ligands, including fibronectin, vitronectin, CD147, or adiponectin (reviewed in Rayes et al. 14), but further studies are needed to address their possible roles.