Besides thrombosis, GPVI also plays a central role in thrombo-inflammatory pathologies as shown in models of acute lung injury and cerebral I/R injury in ischaemic stroke where platelets mainly drive detrimental inflammation, rather than thrombus formation.5,10,30,45,46 In these settings, GPVI may be activated by collagen/fibrin but also other ligands, including fibronectin, vitronectin, CD147, or adiponectin (reviewed in Rayes et al. 14), but further studies are needed to address their possible roles. The gene discussed is GP6; the disease is ischemic stroke.