Ding et al. observed that low shear stress (3–6 dyne/cm2) upregulated the expression of PCSK9 in aortic arch branch points and aorta–iliac bifurcation regions, compared to the thoracic aorta and iliac arteries, these areas being relatively protected from atherosclerosis development [43]. The gene discussed is PCSK9; the disease is atherosclerosis.