Contralateral hemispheres of patients with glioblastoma showed a global increase of the TSPO-PET signal when compared to age- and sex-matched healthy controls (+9%, P = 0.024), whereas patients with IDHmut astrocytoma WHO 2 did not indicate relevant changes compared to healthy controls (±0%, P = 0.99; Fig. 1B and C). Here, TSPO is linked to astrocytoma (excluding glioblastoma).