Although no significant difference could be detected between patients presenting with and without epileptic seizures (P = 0.784, corrected for already initiated glucocorticoid and antiepileptic medication at time of PET), patients with persisting focal or generalized epileptic seizures after initial successful treatment (i.e., temporary absence of solid tumor) of the primary tumor site showed significantly elevated TSPO-PET signals in the contralateral hemisphere (P = 0.040) compared to patients with discontinued seizures (Fig. 3A; additionally corrected for individual tumor therapy regimes). Here, TSPO is linked to neoplasm.