Next, we analyzed the seqlogo of all the LWI regions and compared that with mutations in TRPM8 that are listed in cancer patients which include lymphoid neoplasm, carcinoma, malignant melanoma, pancreatic intraepithelial neoplasia, hematopoietic neoplasm, carcinoid endocrine tumor, primitive neuroectodermal tumor- medulloblastoma, glioma etc. (Fig. 1c). Here, TRPM8 is linked to central nervous system cancer.