GPX4 and lung carcinoma: For instance, Chen et al clarified that curcumin impeded tumorigenesis in follicular thyroid cancer by activating the ferroptosis pathway by increasing the expression of HO-1.9 Zhou et al20 disclosed that curcumin suppressed the GSH-GPX4 and FSP1-CoQ10-NADH pathways to induce ferroptosis, thereby attenuating the self-renewal potential of lung cancer stem cells.