In the CUMS model of depression, quercetin significantly reduces the behavioral signs of stress, and raises superoxide dismutase, catalase and GSH levels while reducing lipid peroxidation and attenuating the expression and levels of the proinflammatory markers IL-6, TNF-α, IL-1β, and COX-2 [31, 49, 50]. This evidence concerns the gene TNF and depressive symptom measurement.