In the CUMS model of depression, quercetin significantly reduces the behavioral signs of stress, and raises superoxide dismutase, catalase and GSH levels while reducing lipid peroxidation and attenuating the expression and levels of the proinflammatory markers IL-6, TNF-α, IL-1β, and COX-2 [31, 49, 50]. The gene discussed is TNF; the disease is major depressive disorder.