NRG1 and schizophrenia: However, none of the existing animal models of schizophrenia, such as MK801, phencyclidine (PCP), and other drug-induced models, or gene knock-out/editing models (DISC-1, NRG-1 knockouts, Dysbindin-1 mutation) [52], or even combined Bdnf-e6 deficiency and developmental stress models [53], have been able to fully replicate the metabolic profile of first-episode drug-naïve (FEDN) SCZ patients.