AKT1 and glioblastoma: To investigate whether the impact of NRBP1 silencing or overexpression on GBM occurred via the PI3K/Akt signaling cascade, U251 cells overexpressing NRBP1 (pcDNA‐NRBP1) were treated with 10 μM AKT inhibitor MK‐2206, and U87 cells with NRBP1 knockdown (sh‐NRBP1) were incubated with 10 μg/mL AKT activator SC79.