PROS1 and liver disorder: Occlusive thrombosis has a more profound impact on the fetus; it may lead to fetal growth restriction, severe IUGR, fetal intolerance to the labor process, fetal distress, neonatal cerebral palsy, cerebral hemorrhage, peritoneal encephalopathy, neurological dysfunction, neonatal liver disease, severe lack of protein S after birth, and even intrauterine fetal death; neonatal death and neonates are more susceptible to develop fetal thrombotic blood vessels [3].