CRP and hydrops fetalis: The qualitative results obtained from various included studies underline significant improvements in crucial clinical parameters such as in the KCCQ-CSS (p< 0.001), body weight (p< 0.001), six-minute walk distance (p< 0.001), and CRP levels (p< 0.001), demonstrating a promising role of semaglutide in the management of MACEs as well as HF with preserved ejection fraction (HFpEF).