The main findings of the current study indicate that increased age, male gender, elevated BMI, the presence of myalgia, coronary artery disease, longer symptom-to-admission interval, and laboratory markers such as neutrophil and lymphocyte counts, CRP, ferritin, troponin, and D-dimer levels, along with NLR and SIRI ratios, were all significantly associated with the need for ARS in COVID-19 patients. The gene discussed is CRP; the disease is coronary artery disorder.