Therefore, authors show that HBV can activate various pathways, such as Phosphatidylinositol 3-kinase-AKT serine/threonine kinase (P13K–AKT), Janus Kinase-Signal transducer and activator of transcription 3 (Jak-STAT3), or Rat sarcoma virus gene-Rapidly accelerated fibrosarcoma (RAS–RAF) (57). Here, STAT3 is linked to fibrosarcoma.