KLK3 and posterior cortical atrophy: Moreover, several previous studies suggest significantly higher percentage of men had a PSA >4 ng/mL found in high PRS compared to low PRS (Sipeky et al., 2020), and the combination of PRS and PSA (or other indicators including PSA, such as prostate health index) could effectively captured participants at both clinical and genetic high risk of PCa, even in patients with gray-zone PSA (Chou et al., 2022; Ruan et al., 2023).