KLK3 and posterior cortical atrophy: Very small difference in PCa risk were observed among subgroups with PSA (−) across different age and PRS, and PCa incidence and mortality with PSA (+) significantly increased as age and PRS, with highest risk for high-PRS/PSA (+) in participants aged ≥70 years [HRs (95%CI): 16.00 (12.62–20.29) and 19.48 (9.26–40.96)].