KLK3 and posterior cortical atrophy: As shown in the age-stratified interaction analyses (Figure 3), compared with low PRS/PSA (−) in participants aged <60 years, HR (95%CI) of PCa incidence were 6.75 (5.47–8.33) for low PRS/PSA (+) and 12.43 (10.09–15.31) for high PRS/PSA (+), respectively, while HR (95%CI) of PCa mortality were 2.95 (1.37–6.35) and 2.74 (1.19–6.28).