They play roles in acne vulgaris (Do et al., 2022; Liu et al., 2023), hidradenitis suppurativa, scar formation (Smith et al., 2023), and vital organ damage in autoimmune diseases such as dermatomyositis (Huang et al., 2022), anti-MDA5 antibody-associated interstitial lung disease (Gono et al., 2022), and lupus nephritis (Valiente et al., 2022). The gene discussed is IFIH1; the disease is interstitial lung disease.