We found that the PON1 -108C/T polymorphism displayed marked relationship with CHD susceptibility (T vs. C: OR = 1.24, 95% CI 1.07–1.45; CT vs. CC: OR = 1.33, 95% CI 1.17–1.52; TT vs. CC: OR = 1.51, 95% CI 1.09–2.09; Recessive model: OR = 1.16, 95% CI 0.93–1.45; Dominant model: OR = 1.45, 95% CI 1.16–1.81). The gene discussed is PON1; the disease is coronary artery disorder.