Reduces anxiety-like behavior and dyskinesia in mice; reduces neuronal degeneration and accumulation of p-α-syn in Lewy bodies and Lewy neurons; reduces expression of pro-inflammatory cytokines (IL-6, IL-1, and TNF-α) while promoting expression of anti-inflammatory cytokines (TGF-β, IL-10, and IL-4). The gene discussed is TGFB1; the disease is Dyskinesia.