NFE2L3 and cancer: Notably, NFE2L3 has been identified as a key player in the development and prognosis of multiple cancer types, including colorectal (Waku and Kobayashi, 2021), liver (Ren Y. et al., 2020), thyroid (Wang et al., 2017), pancreatic (Wang et al., 2018), and renal cancers (Wang et al., 2019; Zhang et al., 2022).