Surprisingly, Gurri et al. (2023) recently reported that TU treatment increased the abundance of NFE2L3 in skin cancer SCC13 cells, and the knockdown of NFE2L3 protected cancer cells from TU-induced apoptosis, possibly because of the stabilization of its partner, heat shock protein family A (Hsp70) member 5 (HSPA5). This evidence concerns the gene NFE2L3 and skin cancer.