NFE2L3 and neoplasm: Additionally, these data suggest that NFE2L3 may affect the tumor immune microenvironment by influencing antigen processing and presentation, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway, lymphocyte-mediated immune regulation, and adaptive immune response, thereby contributing to the development of renal clear cell carcinoma (Wang et al., 2019; Zhang et al., 2022).