Notably, a contrasting role of NFE2L3 was observed in multiple esophageal squamous cell carcinoma cell lines, and in vitro and in vivo experiments showed that the knockdown NFE2L3 enhanced the radiosensitivity of esophageal squamous cell cancer through the transcriptional regulation of IL-6-mediated STAT3 signaling (Chen T. et al., 2022). Here, STAT3 is linked to esophageal squamous cell carcinoma.