Of the matrisome proteins that were differentially expressed in DU145 P and RR sublines, we focused on those that correlate with biochemical recurrence-free survival (BRFS) in the Cancer Genome Atlas Prostate Adenocarcinoma (TCGA-PRAD) gene expression dataset: perlecan/HSPG2 (heparan sulfate proteoglycan 2), SRPX (sushi repeat-containing protein X-linked), LAMB3 (laminin subunit beta 3), and LOXL2 (lysyl oxidase-like 2). This evidence concerns the gene SRPX and prostate adenocarcinoma.