Nevertheless, functional radiobiological clonogenic assay revealed that similar to DU145 RR cells, both LNCaP P and RR cells were radiosensitized by perlecan/HSPG2 knockdown (Figure 5G; Supplementary Figure S6D), indicating that perlecan/HSPG2 could be a potential therapeutic target in androgen-sensitive and androgen-independent PC cells. This evidence concerns the gene HSPG2 and pachyonychia congenita.