PTPN11 and juvenile myelomonocytic leukemia: To elucidate the mechanisms underlying the pathogenesisof PTPN11-mutated JMML, our laboratory created a conditionalPtpn11 allele in mice with thePtpn11E76K mutation, the most commonPTPN11 mutation found in JMML11,12, and developed an inducibledisease model6,18.