Importantly, expression levels ofS100a9 and S100a8 were also elevated approximately 7-fold in leukemic stem/progenitorcells (CD34+) from PTPN11-mutated JMML patients compared tothose in normal CD34+ hematopoietic stem/progenitors (Fig. 8B). This evidence concerns the gene CD34 and juvenile myelomonocytic leukemia.