Notably, when testing the IFNγ+ signature score between immune high and low cluster tumors, immune high tumors had significantly higher signatures scores irrespective of the breast cancer subtype (HR+ HER2− Mann-Whitney test, P-value = 6.3×10− 62, TN Mann-Whitney test, P-value = 1.3×10−18). The gene discussed is ERBB2; the disease is breast cancer.