Indices of inflammation [e.g., circulating levels of cytokines (e.g., interleukin-6 (IL-6) and acute phase proteins (e.g., C-reactive protein (CRP)] are elevated in individuals with depression compared to controls12 and inflammatory biomarkers have been linked to specific aspects of depression, such as anhedonia and negative affect13, 14. The gene discussed is IL6; the disease is depressive disorder.