SLC44A4 and infection: Indeed, this was observed with CTL4 whose silencing by RNAi, though highly efficient (Schnitger et al., 2009), triggered strong yet partial melanization of P. berghei ookinetes (Osta et al., 2004) and weak melanization of P. falciparum ookinetes observed only at high infection levels (Simoes et al., 2017), however, CTL4 knockout completely melanized P. berghei and strongly melanized P. falciparum ookinetes (Simoes et al., 2022).