WHSC1 overexpression in t(4;14) tumors increases dimethylation of H3K36 and broadly dysregulates the myeloma epigenome.54 The coverage heat map showing where discordant barcodes map on chr4 and chr14 clearly shows the translocation breakpoint within the first intron of WHSC1 at chr4:1871962 and near IGHM on chr14 and also indicates a deletion proximal to the translocation breakpoint on chr14. The gene discussed is NSD2; the disease is plasma cell myeloma.