TFE3 and nonpapillary renal cell carcinoma: Interestingly, knockout of wild type TFE3 in a ccRCC cell line (786-O) did not lead to decreased expression of OXPHOS related genes (Extended Data Fig. 2g), nor were there effects on TCA cycle or arginine biosynthesis-related metabolites (Extended Data Fig. 2h–i) or on OCR (Extended Data Fig. 2j), suggesting that this activity may be a selective property of the constitutively active TFE3 fusion.