Indeed, we observed that, despite higher levels of HIF1A mRNA in tRCC vs. ccRCC tumors, a HIF1A gene signature was relatively suppressed in tRCC tumors, consistent with active degradation of HIF-1a by the EGLN1-VHL axis in tRCC (Fig. 3c and Extended Data Fig. 5a–b). This evidence concerns the gene EGLN1 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.