To gain further insight into the mechanism by which OXPHOS inhibition (either by TFE3 fusion inhibition or EGLN1 inhibition) could impair fitness in tRCC, we overlapped gene dependencies in s-TFE cells with hits from a prior CRISPR screen that identified modulators of NRF2 sensitivity41. This evidence concerns the gene EGLN1 and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions.