HIF1A and renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions: We conclude that EGLN1 represents a strong and selective vulnerability in tRCC, likely driven by a mechanism of HIF-1α stabilization that results in metabolic reprogramming away from OXPHOS and toward glycolysis, which is detrimental to tRCC cells (Fig. 3k).