Downregulation of FN3K in liver (HepG2, Huh1 lines) and lung (H3255, H460 lines) cancer cell lines resulted in the impairment of NRF2 function by reducing its protein stability and disrupting its dimerization with the small musculoaponeurotic fibrosarcoma (sMAF) proteins, all of which are critical for NRF2 function (29–31). The gene discussed is FN3K; the disease is cancer.