Moreover, of the cancer genes with putative functional consequences driven by CLK1 splicing, we discovered that 2.3% (N = 6) had dysregulation at the level of both splicing and expression (Figure 4N), including gene encoding IKBKE, PLD1, IRF1, ATF3, CEACAM1, and ROBO1, indicating these may impact the tumor’s proteome. The gene discussed is IRF1; the disease is cancer.