IKBKE and cancer: Moreover, of the cancer genes with putative functional consequences driven by CLK1 splicing, we discovered that 2.3% (N = 6) had dysregulation at the level of both splicing and expression (Figure 4N), including gene encoding IKBKE, PLD1, IRF1, ATF3, CEACAM1, and ROBO1, indicating these may impact the tumor’s proteome.