Several studies have shown that the cGAS-STING pathway is activated in the brain of aged mice and humans, as well as in mouse models of Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS) (Yu et al., 2020; Hinkle et al., 2022; Tan et al., 2022; Xie et al., 2023). This evidence concerns the gene CGAS and Alzheimer disease.