However, recent studies have revealed that the cGAS-STING pathway can also contribute to chronic inflammation and tissue damage in various pathological conditions, such as autoimmune diseases, cancer, and neurodegeneration (Ahn et al., 2014, 2018; Woo et al., 2014; West et al., 2015; Abdullah et al., 2018; Choi et al., 2020; Hinkle et al., 2022; Skopelja-Gardner et al., 2022; Zhao J. et al., 2022; Gulen et al., 2023; Xie et al., 2023). This evidence concerns the gene STING1 and cancer.