Meanwhile, the index of total glucagon response (iAUC0-180 glucagon) in the T1D group were higher than that in the healthy control group [398·00 (37·10; 689·00) vs. -960·00 (-1449·75; -493·25) pmol/L*min, P < 0·001]. The gene discussed is GCG; the disease is type 1 diabetes mellitus.