INS and obesity due to melanocortin 4 receptor deficiency: Figure 7A illustrates the top 10 keywords with high frequency, covering topics such as “type 2 diabetes,” “insulin resistance,” “physical activity,” “skeletal muscle,” “exercise,” “mechanism,” “oxidative stress,” “obesity,” “cardiovascular disease,” and “metabolic syndrome.” Furthermore, we showcased keywords with a centrality exceeding 0.1, as depicted in Figure 7B.