The HSP90 family, including Heat Shock Protein 90 Alpha Family Class A Member 1 (HSP90AA1), Heat Shock Protein 90 Alpha Family Class B Member 1 (HSP90AB1), HSP90B1, and TNF Receptor Associated Protein 1 (TRAP1), plays a pivotal part in various cellular processes and in the folding of client proteins involved in cancer development [23]. The gene discussed is TRAP1; the disease is cancer.