In addition, SPDL1 overexpression correlated with the poor prognosis of the patients with different malignancies, such as colorectal cancer (CRC) [7], pancreatic ductal adenocarcinoma [12,13], oral squamous cell carcinoma (OSCC) [14], lung cancer [[15], [16], [17]], and esophageal cancer (ESCA) [18]. Here, SPDL1 is linked to pancreatic ductal adenocarcinoma.