However, we observed a sex-biased interaction of Ret and Apc: total (colonic plus small intestinal) tumor burden was significantly greater in female ApcMin/+Ret+/− mice compared to male ApcMin/+Ret+/− mice (3-way ANOVA, interaction between Apc, Ret, and sex covariates: p<0.003, F1,74 = 10; Figure 1B). Here, APC is linked to neoplasm.