Furthermore, tumor cells can control osteoclast precursors, as evidenced by a study demonstrating that HCC cells secreting lectin galactoside‐binding soluble 3(LGALS3) can induce the fusion and podosome formation of osteoclasts through the CD98–integrin αvβ3 complex, resulting in osteolytic bone remodeling (23). This evidence concerns the gene LGALS3 and neoplasm.