WT1 and Li-Fraumeni syndrome: Conditions associated with a slightly increased risk include Beckwith–Wiedemann syndrome (4% risk), Simpson–Golabi–Behmel syndrome (3% risk), Bloom syndrome (3% risk), WT1 splice mutations (Frasier syndrome), Li-Fraumeni syndrome, hereditary hyperparathyroidism–jaw tumor syndrome, Mulibrey nanism, Trisomy 13 and 18, and 2q37 deletions (5, 18).