WT1 and aniridia: Conditions found to have a significantly increased risk in children include WT1 deletions and missense mutations, such as WAGR (acronym for Wilms tumor, aniridia, genitourinary malformations and a range of mental disabilities) syndrome (50% risk of developing WT) and Denys–Drash syndrome (up to 75% risk of developing WT), familial WT (2% of all WTs have a family history), Perlman syndrome (55% of those who survive infancy develop WT), mosaic variegated aneuploidy (roughly 85% risk), and Fanconi anemia (20–60% risk) (5, 17, 18).