IFNG and paracoccidioidomycosis: found that the expression of IFN-γ and interleukin-12A (IL-12A) was significantly increased in PCM breast tissues (39), and IFN-γ and IL-12A were able to activate the Th1 cell subpopulation at the same time, indicating that there may be over-activation of Th1 cells in PCM patients.