In our research, based on the ‘ESTIMATE’ and deconvolution algorithms, AUNIP shows a significant positive correlation with tumor purity scores, and a negative correlation with immune scores, B cells, CD8+ T cells, and CD4+ T cells in the lung adenocarcinoma cohort from the TCGA database (Supplementary Figures 2C–H). This evidence concerns the gene CD8A and lung adenocarcinoma.