CD4 and neoplasm: Immune cells such as CD8+ T cells, activated memory CD4+ T cells, and Macrophages M0/M1 were significantly upregulated in the C2 type and low NMRS group, while Macrophages M2, Dendritic cells, etc., were significantly upregulated in the C1 type and high NMRS group, indicating that patients with C2 type and low NMRS group tend to have a more active tumor microenvironment (Figures 5A, B).