Mechanistically, spontaneous orthotopic lung cancer models have been shown to secrete a soluble form of the receptor for advanced glycation end products (sRAGE) which can provoke osteocalcin+ osteoblast activity with enhanced CXCR2 expression and subsequent mobilization of tumor-infiltrating SiglecFhi Neu (127, 128). The gene discussed is CXCR2; the disease is neoplasm.