- BMN basophils are dominant IL4 source → - basophil depletion reduces immune-suppressive myelopoiesis + tumor burden- 8 tumor-derived cytokines synergistically result in IL4 upregulation in basophils: IL18, VEGF-A, IL6, IL1α, IL7, CCL3, IL15 and CSF2. The gene discussed is VEGFA; the disease is neoplasm.