- In vitro: BC cell-derived G-CSF can synergize with FLT3L and GM-CSF to expand myeloid progenitors and progeny (but NOT for B16 nor CMT96 colon carcinoma lines)- °histone methylation changes within HSCs in the BMN of tumor bearing mice correlated with gene dysregulation of the Hox family and PRC2 chromatin-remodeling complex (diminished Ezh2 expression, reduced H3K27me3, and Hoxa9 upregulation). Here, CSF2 is linked to breast cancer.