CXCR4 and colorectal neoplasm: - Blood: decrease in CMPs <-> no differences in MEPs nor CLPs <-> increase in HSCs and MPPs and especially GMPs (4-7 fold) → only CD15+/CD133int/+ granulocytic precursors and subsets up-regulated <-> declined lymphoid potential) + association between circulating GMP levels and disease progression- Colorectal tumor tissue: increase in CD133+ HSCs that co-express myeloid markers CD15 or CD14 + were mainly positive for CXCR4+