- tumor-induced GCSF is both necessary and sufficientto reduce cDC1 differentiation by downregulating IRF8 in cDC progenitors (MDPs, CDPs and pre-DCs) directly via STAT3 activation<-> IL6 neutralization reduced immature granulocytes and inflammatory Mo yet not reversed tumor-induced reductions in pre-DCs or cDC1s in BM. The gene discussed is IRF8; the disease is neoplasm.