- Blood: °anemia <-> increase in leukocytes- BMN: increase in immature erythroblasts and % of myeloid cells <-> reduced differentiation of MPPs → proportion of LT-HSC, ST-HSC, and MPP stayed unchanged yet CMP/MPP and CLP/MPP ratios decreased- BMN stroma: 1) bone volume/total volume, trabecular number, and cortical wall thickness decreased, 2) osteoclast # increased next to expression of osteoblastic (Runx2, Alpl) and osteoclastic genes (Ctsk and Acp5), 3) reduced growth rate of MSCs with elevated osteogenic but reduced adipogenic potential, CXCL12 and SCF expression. The gene discussed is ALPL; the disease is anemia (phenotype).