IRF8 and anemia (phenotype): - MEP → °CD45+ erythroid progenitor cells in spleen and BMN which don’t differentiate to erythrocytes but de-differentiate into multipotent state termed erythroid differentiated myeloid cells with myeloid lineage markers IRF8 and PU.1 and silencing of erythroid lineage markers Gata1 and Klf1 → ° anemia, T cell exhaustion and resistance to anti-PD-(L)1 ICB