In addition, breast cancer-derived ATP has been shown to activate the NLRP3/inflammasome and release IL1β by BMN-residing Nestin1+ CXCL12 secreting MSCs which results in decreased CXCL12 and SCF expression to increase HSC mobilization, ATF3 promoting CMP/GMP cluster formation and expansion of CD14+ Mo that differentiate to tumor-associated macrophages (TAMs) (139, 140). The gene discussed is CXCL12; the disease is breast cancer.