ATP release from BC → °enhanced activation of NLRP3/inflammasome and release of IL1B by BM-MSCs → upregulation and nuclear translocation of ATF3 in BMN → °increased density of Nestin+ CXCL12 secreting MSCs and myeloid populations at expense of erythroid and B cellsAt early stage: ATF3 in HSCs → promotion of CMP/GMP cluster formation <-> At later stage: expansion and release of CXCR4+ ATF3+ CD14+ Mo-myeloid cells that differentiate into Macs in periphery- Deregulation of circulating miRNAs were predicted regulators of downregulated transcripts in BM. The gene discussed is NES; the disease is breast cancer.