In IL4raΔMs4a3-cre mice (vs wt) tumor bearing mice:- 85% reduction in tumor burden IL4raΔMs4a3-cre mice <-> no difference when IL4ra ko in DC, Mo, Neu, Mac or T cells- °inflamed antitumor lung TME state- reduced GMP expansion- Mo expressed higher vs lower levels of genes associated with maturation vs early stages of myeloid development. The gene discussed is KRT8; the disease is neoplasm.