- patient BM: decreased # of CDPs, pre-DCs, cDC1s and cDC2s <-> expansion of BMN immature granulocytes <-> MDPs reduced in BC but not PDAC patients- mouse BM: similar except for inconsistent decrease in cDC2s (unlike cDC1s)- patient blood: also reduction in pre-DC <-> increase in immature granulocytes- impaired priming of CD8+ T cells and correlation with poor patient outcomes. Here, CD8A is linked to breast cancer.