Previous studies have reported on various imaging features that may be more frequently seen or even be distinct in MOGAD compared to MS and AQP4-IgG-positive NMOSD.1 To add to the growing literature on this, we assessed the MRI available at first attack for the frequency of typical imaging features of MOGAD and atypical features more suggestive of MS or AQP4-IgG-positive NMOSD in the true-positive cases. Here, AQP4 is linked to myeloid sarcoma.