(1) PM may be involved in different life cycle stages of COVID-19, including alteration of SARS-CoV-2 viral receptors and proteases required for entry (e.g., angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine type 2 (TMPRSS2), proteins and protease critical to SARS-CoV-2 entry into host cells) (39), inhibition of mucosal ciliary clearance, alteration of antiviral interferon production and viral replication (40). This evidence concerns the gene TMPRSS2 and COVID-19.