Recent research has revealed that these effects are mediated by SIRT3 (D'Onofrio et al., 2023), a highly expressed mitochondrial deacetylase, which plays a vital role in preventing AKI by regulating energy metabolism, inhibiting oxidative stress, suppressing inflammation, improving apoptosis, inhibiting early fibrosis, and maintaining mitochondrial homeostasis (Yuan et al., 2023). The gene discussed is SIRT3; the disease is acute kidney injury.