GAPDH and Hyperglycemia: The inhibition of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by mitochondrial overproduction of ROS resulting from hyperglycemia increases triose phosphate levels and then promotes the generation of AGEs (Table 1) (Du et al., 2000; Del Turco and Basta, 2012; Sergi et al., 2021).