Activation of PKC mediated by hyperglycemia can affect the permeability of vascular ECs, systolic and diastolic balance of vascular smooth muscle, blood flow, and aggregation and invasion of inflammatory cells, causing vascular dysfunction (Koya and King, 1998; Geraldes et al., 2009; Volpe et al., 2018). Here, PRRT2 is linked to Hyperglycemia.