NPPB and hydrops fetalis: Focusing on the impact of HF on brain structure, Mueller et al. (2020) found that biomarkers of heart failure, such as left ventricular ejection fraction (LVEF) and N-terminal prohormone brain natriuretic peptide (NT-proBNP) levels, were linked to decreased gray matter density across the entirety of the frontomedian cortex, hippocampus, and precuneus.