Adult diffuse gliomas can be divided into three categories according to the presence or absence of IDH mutation and 1p and 19q (1p/19q) deletion: astrocytoma, IDH-mutant; Oligodendroglioma, IDH mutation with 1P19q co-deletion; Glioblastoma, IDH wild-type (Wagner et al., 2024) (Figure 1). Here, IDH1 is linked to glioblastoma.