In keeping with this conclusion, PTEN‐deficient human NSC undergo malignant transformation when injected into the brain of immunocompromised NOD/SCID mice, giving rise to tumours expressing SOX2, GFAP, NESTIN, TUJ1, MAP2, and CD133, similarly to human glioblastoma [147]. This evidence concerns the gene SOX2 and glioblastoma.