TUBB3 and Global developmental delay: CFEOM without systemic disorders was present in patients with the c.784 C > T(p.Arg262Cys), c.904G > A(p.Ala302Thr), and c.1249G > A(p.Asp417Asn) variants of TUBB3, whereas a complicated systemic disorder was observed in patients with the c.1228G > A(p.Glu410Lys) variant of TUBB3, including developmental delay and Kallmann syndrome in all four patients (S16, S17, S26, and S27), facial weakness in three patients (S16, S17, and S27), and vocal cord paralysis in two patients (S16 and S17) (Table 1).