Given the strong association between ZDHHC6 and PPARγ, as well as the crucial role of ZDHHC6 as a palmitoyltransferase in various biological processes, we hypothesized that ZDHHC6 may regulate the palmitoylation of PPARγ in response to alterations in lipid metabolism that occur during the progression of CRC. This evidence concerns the gene PPARG and colorectal carcinoma.