ZDHHC3 exacerbates the development of nonalcoholic steatohepatitis (NASH) and the progression of hepatocellular carcinoma (HCC) associated to NASH by boosting the accumulation of lipids regulated by IRHOM2 and the production of lipids mediated by FASN signaling [35]. The gene discussed is FASN; the disease is metabolic dysfunction-associated steatohepatitis.