In addition, an examination of the TCGA-CRC and ICGC-CRC databases revealed a substantial correlation between ZDHHC6 and the PPARγ pathway in CRC, as demonstrated in Fig. 5J. In summary, our findings validate that ZDHHC6 has a unique interaction with PPARγ, a crucial transcription factor involved in lipid metabolism. This evidence concerns the gene ZDHHC6 and colorectal carcinoma.