The first three enrichment pathways of PIK3CB are galactose metabolism, RIG I like receptor signaling pathway and amino sugar and nucleotide sugar metabolism (Fig. 6B); The top three enrichment pathways of OSMR are notch signaling pathway, galactose metabolism and RIG I like receptor signaling pathway (Fig. 6C); The first three enrichment pathways of CXCR6 are renal cell carcinoma, galactose metabolism, and notch signaling pathway (Fig. 6D). The gene discussed is OSMR; the disease is hereditary clear cell renal cell carcinoma.