Performing multiple linear regression analysis showed that LV-GLS (p < 0.001, 95%CI = -1.694 to -0.548), SDNN (p < 0.001, 95% CI =  − 0.141 to − 0.063), LF/HF (p < 0.003, 95%CI = 1.587 to 3.708), PCFS (p < 0.02, 95% CI = 0.429 to 4.368) and CRP (p < 0.0001, 95% CI = 0.407 to 1.020) were independently associated with the occurrence of ventricular arrhythmia in symptomatic post-COVID patients. The gene discussed is CRP; the disease is Ventricular arrhythmia.