Of note, HRG has been reported to suppress sepsis and tumor metastasis, inhibit hyperinflammation in acute pancreatitis, and relieve liver ischemia/reperfusion injury (Guo et al, 2021; Kuroda et al, 2021; Terao et al, 2018; Tomonobu et al, 2022; Yin et al, 2023). The gene discussed is HRG; the disease is Sepsis.