PLAT and hematocrit: To our surprise, insufficient HRG increases at 1 h post-tPA infusion correlated with increased risk of developing HT within 24 h of tPA treatment, which appears unexpected based on previous reports regarding its physio-pathological role in thrombosis (Malik et al, 2021; Shigekiyo et al, 1998; Vu et al, 2015).