Differential gene expression analysis between TAF-present/SARIFA-negative CRCs (only TAF) and SARIFA-positive (and TAF-present, double positive) CRCs revealed among the 60 upregulated genes in the double positive CRCs (LFC > 0, no LFC threshold, q ≤ 0.05) several genes that are involved in lipid metabolism (FABP4, PLIN1, ADIPOQ, PLIN4, CD36; see Supplementary Table 3, see Supplementary Data 2), again suggesting that direct tumor-adipocyte interaction may not only have prognostic but also biologic implications. This evidence concerns the gene PLIN1 and neoplasm.